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In vitro experiments performed on embryonic forebrain-derived NSPCs revealed that hops ( Humulus lupulus L.)-derived prenylflavonoidsthe most potent type of phytoestrogens reported so farcan induce neurite outgrowth of dorsal root ganglion neurons and neuronal differentiation of NSPCs, measured by the activation of the promoter of neuronal fate-specific doublecortin (DCX) gene (Oberbauer et al., 2013)